Complexitatea Dinamicii Corticale n Timpul Legrii Perceptuale: Oscilaii Gamma


Rezumat

Una dintre cele mai importante funcii ale sistemului vizual uman este legarea perceptual (perceptual binding), un proces care st la baza capacitii noastre de a percepe lumea. Recent, s-a artat c oscilaiile corticale n banda gamma joac un rol crucial n acest proces. Vom investiga, folosind nregistrri electroencefalografice (EEG) de mare densitate, pe subieci umani, funcia oscilaiilor gamma pentru legarea perceptual. Rolul activitii gamma va fi studiat din dou perspective. n primul rnd, aceasta ar putea reprezenta un mecanism pentru explorarea spaiului de stri corticale, naintea gsirii unei soluii pentru codificarea scenei vizuale. A doua posibilitate este c oscilaiile gamma sunt un mecanism direct implicat n reprezentarea soluiei vizuale. Aceste ipoteze vor fi testate folosind o paradigm psihofizic de legare perceptual. n paralel, vom investiga evoluia complexitii semnalului EEG ca funcie de dificultatea taskului perceptual. Se vor aplica metode non-liniare avansate, bazate pe dimensiunea fractal, descriptori TESPAR i analiza de pattern-uri multi-dimensionale, dezvoltate deja de membri grupului de cercetare. Prin utilizarea acestor metode, intenionm s studiem ipoteza conform creia sistemele neuronale rezolv probleme (vizuale) prin explorarea unui spaiu hiper-dimensional de stri i selecia consecutiv a soluiei pe baza unor atractori nvai n prealabil. Accent special se va pune pe rolul oscilaiilor gamma n timpul procesului perceptual i corelaia acestora cu complexitatea semnalului EEG. Implicaiile poteniale ale proiectului sunt vaste. Acesta va contribui la o mai bun nelegere a oscilaiilor gamma, cunoscute a fi implicate n boli neurologice ca: schizofrenia, epilepsia, autismul, bolile Alzheimer i Parkinson. Mai mult, ne va ajuta la o mai bun nelegere a proceselor care stau la baza percepiei vizuale, cu implicaii importante att pentru industrie ct i pentru societate.


Echipa de cercetare

Dr. Ing. Raul C. Murean, director de proiect. Grad de implicare n proiect > 75%.

[Pagina personal]    [Curriculum Vitae]
Dipl. Ing. Vlad V. Moca, cercettor doctorand. Grad de implicare n proiect > 86%.

[Curriculum Vitae]
Ioana Ţinca, cercettor doctorand. Grad de implicare n proiect > 76%.

[Curriculum Vitae]
Dipl. Ing. Ovidiu F. Jurju, cercettor doctorand. Finanare extern (Germania).

[Curriculum Vitae]
Dr. Rzvan V. Florian, cercettor cu experien (postdoc).

[Pagina personal]


Obiective i activiti

  • Raport de activitate pe anul 2007.
     [pdf]

  • Raport de activitate pe anul 2008.
     [pdf]

  • Raport de activitate pe anul 2009.
     [pdf]

  • Raport final de activitate (2010).
     [pdf]



Rezultate

  • Sinteza lucrrii pe anul 2007.
     [pdf]

  • Sinteza lucrrii pe anul 2008.
     [pdf]

  • Sinteza lucrrii pe anul 2009.
     [pdf]

  • Sinteza lucrrii (final 2010).
     [pdf]



Publicaii

Articole:

  • Moca V.V., Tincas I., Melloni L., Muresan R.C. (2011), Visual exploration and object recognition by lattice deformation. PLoS One 6(7): e22831.
     [pdf]  [link]

  • Jurjut O.F., Nikolic D., Pipa G., Singer W., Metzler D., Muresan R.C. (2009), A color-based visualization technique for multi-electrode spike trains. Journal of Neurophysiology 102:3766-3778, 2009.
     [pdf]

  • Moca V.V., Scheller B., Muresan R.C., Daunderer M., Pipa G. (2009), EEG under anesthesia - feature extraction with TESPAR. Computer Methods and Programs in Biomedicine 95:191-202.
     [pdf]

  • Muresan R.C., Jurjut O.F., Moca V.V., Singer W., Nikolic D. (2008), The Oscillation Score: An Efficient Method for Estimating Oscillation Strength in Neuronal Activity. Journal of Neurophysiology 99:1333-1353.
     [pdf & free source code]

  • Nikolic D., Moca V.V., Singer W. and Muresan R.C. (2008), Properties of multivariate data investigated by fractal dimensionality. Journal of Neuroscience Methods 172(1):27-33.
    [link]

  • Muresan R.C., Singer W., Nikolic D. (2008), The InfoPhase Method or How to Read Neurons with Neurons. In V. Kurkova et al. (eds.): ICANN 2008, Part II, Lecture Notes in Computer Science 5164, pp. 498-507, Springer, Berlin / Heidelberg.
     [pdf] [link]

  • Moca V.V., Nikolic D., and Muresan R.C. (2008), Real and Modeled Spike Trains: Where Do They Meet? In V. Kurkova et al. (eds.): ICANN 2008, Part II, Lecture Notes in Computer Science 5164, pp. 488-497, Springer, Berlin / Heidelberg.
     [pdf] [link]

Rezumate, rezumate extinse, postere i prelegeri invitate:

  • Muresan R.C. (2009), Combined Approaches to Understanding the Brain, invited talk at Seminari di Neuroscienze e Scienze Psichologiche e Psichiatriche, University of Verona, Verona, Italy.

  • Muresan R.C., Tincas I., Moca V.V., Melloni L. (2009), Probing the visual system with visual hypotheses, (CNS Meeting 09) Berlin Germany: BMC Neuroscience 10 (Suppl 1), p. 356.
     [pdf] [link]

  • Moca V.V., Scheller B., Muresan R.C., Daunderer M., Pipa G. (2009), EEG processing with TESPAR for depth of anesthesia detection, (CNS Meeting 09) Berlin Germany: BMC Neuroscience 10 (Suppl 1), p. 68.
     [pdf] [link]

  • Muresan R.C., Tincas I., Moca V.V., Melloni L. (2009), Vision by inference: visual recognition under uncertainty, (ASSC XIII) Berlin Germany, p. 195.
     [link]

  • Moca V.V., Scheller B., Muresan R.C., Daunderer M., Pipa G. (2009), Importance of EEG frequency bands in the assessment of depth of anesthesia, (ASSC XIII) Berlin Germany, p. 187.
     [link]

  • Muresan R.C. (2009), Investigating Brain Function from Multiple Perspectives: Modeling, Experiment, Analysis, invited talk at AHFMR Polaris Mini Workshop on Brain Dynamics, Canadian Centre for Behavioural Neuroscience, Lethbridge, Canada.

  • Muresan R.C. (2008), Dynamics of self-sustained microcircuits examined with regular-spiking readouts, (CNS Meeting 08) Portland (Oregon), USA: BMC Neuroscience 9 (Suppl 1), p. 37.
     [pdf] [link]

  • Jurjut O.F., Nikolic D., Singer W., Metzler D., Muresan R.C. (2008), Multidimensional Patterns of Neuronal Activity: How do we see them?, (CNS Meeting 08) Portland (Oregon), USA: BMC Neuroscience 9 (Suppl 1), p. 128.
     [pdf] [link]

  • Jurjut O.F., Nikolic D., Singer W., Metzler D., Muresan R.C. (2008), Exploring Parallelly Recorded Spike Trains, (Cosyne 08) Salt Lake City, USA, I-33.
    [pdf]

  • Muresan R.C. (2007), Do I integrate or do I resonate? That is the question! Coherent Behavior in Neural Networks (CoBeNN) Mallorca, Spain, P23.
     [pdf]

  • Jurjut O.F., Nikolic D., Metzler D., Singer W., Muresan R.C. (2007), Vizualizing Multi-dimensional Neuronal Data, Coherent Behavior in Neuronal Networks (CoBeNN) Mallorca, Spain, P16.